A COMPUTATIONALLY EFFICIENT ALGORITHM TO LEVERAGE AVERAGE INFORMATION REML FOR (CO)VARIANCE COMPONENT ESTIMATION IN THE GENOMIC ERA

A computationally efficient algorithm to leverage average information REML for (co)variance component estimation in the genomic era

Abstract Background Methods for estimating Leather Valet Tray variance components (VC) using restricted maximum likelihood (REML) typically require elements from the inverse of the coefficient matrix of the mixed model equations (MME).As genomic information becomes more prevalent, the coefficient matrix of the MME becomes denser, presenting a chall

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Canonical Wnt Signaling Promotes Formation of Somatic Permeability Barrier for Proper Germ Cell Differentiation

Morphogen-mediated signaling is critical for proper organ development and stem cell function, and well-characterized mechanisms spatiotemporally limit the expression of ligands, receptors, and ligand-binding cell-surface glypicans.Here, we show that in the developing Drosophila ovary, canonical Wnt signaling promotes the formation of somatic escort

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Social Innovation in Education and Social Service Organizations. Challenges, Actors, and Approaches to Foster Social Innovation

Social innovation became a widely discussed topic in politics, research funding programs, and business development.Recent European and US economic and science policies have set aside significant funds to generate and foster social innovation.In view of current challenges such as digitization, Work 4.0, inclusion or migrant integration, the question

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